July 10, 2015
“Cancer Research UK scientists have found that ‘jumping genes’ may add to the genetic chaos behind more than three-quarters of esophageal cancer cases, according to research published in BMC Genomics.
The scientists, from the University of Cambridge, used cutting-edge technology that can read DNA to study the genes of 43 esophageal tumour and blood samples to discover how much these mobile genetic sequences travel.
‘Jumping genes’, called L1 elements, can uproot themselves and move to new areas in the DNA, sometimes accidentally moving into genes that control the cell’s growth.
They found evidence that this happened around 100 times in each tumour sample, and in some tumours it happened 700 times.
If a jumping gene lands in or near an important gene that controls cell growth, it can wreak havoc, changing how the gene works so that it inadvertently tells the cell to grow and divide out of control – which could lead to cancer.
Study author Dr Paul Edwards, at the Cancer Research UK Cambridge Institute, said: “These jumping genes play hopscotch across our genetic code in cancer cells more than in normal cells. When one of these mobile genetic sequences plants itself in the middle of a gene that controls the cell’s growth it radically alters how the cell behaves, which can sometimes cause cancer.
“Research has shown that this might also happen in lung and bowel cancers. So it’s vital we find out more about how the cells do this in a bid to find ways to treat these cancers.”
The research is part of the International Cancer Genome Consortium (ICGC) – a global project using the latest gene sequencing technology to reveal the genetic changes behind cancer. The esophageal cancer project is funded by Cancer Research UK.
Dr Kat Arney, Cancer Research UK’s science information manager, said: “Esophageal cancer is one of the hardest cancers to treat, and we are committed to funding more research to find out its underlying causes. These new findings reveal more about the genetic chaos that underpins esophageal tumours, and could one day help us develop better ways to diagnose, treat and monitor the disease.”
References: Paterson et al. Mobile element insertions are frequent in oesophageal adenocarcinomas and can mislead paired end sequencing analysis. BMC Genomics. DOI: 10.1186/s12864-015-1685-z.
This post is based on materials provided by Cancer Research UK.
The Salgi Esophageal Cancer Research Foundation is a 501 (c) (3) non profit organization as recognized by the Internal Revenue Service.
Content found on Salgi.org is for informational purposes only. The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.
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Posted by salgiblogs
June 2, 2015
The Salgi Esophageal Cancer Research Foundation would like to congratulate our Vice President for receiving a Rising Star Award from NonProfit PRO’s 2015 Nonprofit Professionals of the Year.
This achievement was featured in NonProfit PRO’s May 2015 issue which featured the 2015 Nonprofit Professionals of the Year Awards. Below is an excerpt from the magazine.
“Due to our Vice President’s social media and Internet optimization efforts, we have been able to connect with people across the United States, Canada, Australia, Philippines, India, Egypt and the United Kingdom. As a newer nonprofit with very limited funds, she has utilized low to no-cost marketing avenues to bring our message to the masses. Through social media, Google Ad Grants, our website, email newsletters, blogs, print, mailings and so much more, we have been fortunate enough to not only survive these hard times in our first years, but thrive with the promise of better times.”
– President, The Salgi Esophageal Cancer Research Foundation
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Posted by salgiblogs
February 7, 2012
One way to treat gastroesophageal reflux disease (GERD) is through changes in diet and nutrition. Of course, this approach must be discussed with your doctor before attempting to put into place on your own. While making changes in your diet may be extremely helpful for some it can also be challenging. Many are not sure what foods are “safe” to eat and end up wandering aimlessly in the grocery store on their shopping trips.
Below is a list that we have put together of foods which have been shown to be suitable for GERD sufferers. The best practice is to “test” certain foods and see how your body reacts to them. Everyone will react differently to different foods. Keeping a food journal with details of what you’ve had to eat or drink can help you keep track of what affects your reflux. Write down everything that you’ve had to eat or drink along with what time of the day and if you’ve had any symptoms from the food or drink.
When grocery shopping, consider the size of the item you are buying. Another easy way to reduce your acid reflux or GERD is to reduce portion sizes. Eating smaller meals has proven to reduce episodes of GERD.
GERD Grocery Shopping List
Apple- juice, dried or fresh
Banana
Pears
Potato
Broccoli
Cabbage
Carrots
Celery
Corn
Beans
Lentils
Mushrooms
Parsnips
Peas
Spinach
Kale
Squash
Green beans
Brown Rice
Multi-grain or whole wheat bread
Bran Cereal
Oatmeal
Corn Bread
Graham Crackers
Pretzels
Rice cakes
Feta cheese
Goat cheese
Fat-free cream cheese
Fat-free sour cream
Low-fat soy cheese
Skim milk
Egg substitute
Egg whites
Skinless chicken breast
Extra lean steak
Extra lean ground beef
Salmon
Fish – no added fat
Ginger
Honey
Basil
Cilantro
Chamomile tea
As always, consult your doctor before making any lifestyle changes.
These suggestions are for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.
Sources:
Magee, Elaine. “Heartburn: Foods to Avoid.” WebMD, WebMD, http://www.webmd.com/heartburn-gerd/features/heartburn-foods-to-avoid#1.
Johnson, Jon. “Diet Tips for GERD: Foods to Eat and Avoid.” Medical News Today, MediLexicon International, http://www.medicalnewstoday.com/articles/314690.php.
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The Salgi Esophageal Cancer Research Foundation 